Research - Molecular
mechanisms of new
antiparasitic drugs and
evolution study of malaria
parasites
(mitochondria-based).

The Structural Biology and Cell Signaling Research Group focuses on exploring structural and molecular biology to understand disease mechanisms and develop innovative therapeutic solutions. Our research includes structural studies of proteins using Cryo-EM to uncover the dynamics of proteins involved in endocrine diseases and diabetes mellitus, including the interaction of glycosylated human serum albumin with bioinorganic compounds as drug candidates. We also investigate the molecular mechanisms of new antiparasitic drugs and the evolution of mitochondria-based malaria parasites, supported by the identification of malaria in humans and non-human primates using mitochondrial markers. Antimalarial drug screening is conducted using Plasmodium berghei mutant rodent models, complementing our focus on antimalarial therapy development. Additionally, our group studies genotype-phenotype relationships in thalassemia and mutation mechanisms in disease pathogenesis, with an emphasis on molecular analysis to understand the clinical manifestations of thalassemia. In the context of tissue regeneration, we develop innovative biomaterial prototypes such as silk-based nanofibers and polyhydroxyalkanoates for cartilage and bone regeneration, as well as alginate/nanocellulose/ZnO hydrogels for skin regeneration and wound healing. These technologies are supported by freeze-dried secretomes for clinical applications. We also explore the potential of herbal remedies in mesenchymal stem cell proliferation and differentiation as disease models and regenerative therapy. Through the integration of Cryo-EM, bioinformatics, and experimental cell-based approaches, the Structural Biology and Cell Signaling Research Group is committed to advancing scientific understanding and making a tangible impact in health and biotechnology.

Scope of Work:

• Screening new antimalarial drugs using Plasmodium berghei mutant rodent models against known antimalarial drugs.
• Identification of malaria in humans and non-human primates using mitochondrial markers.

Relevant Study Program/Department: Biology, Biochemistry, Chemistry, Pharmacy

MBKM Implementation Location: Genomics Laboratory, Soekarno Science and Technology Area (Cibinong).

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